Share on Twitter Add to Google Plus Share on Facebook Email a Friend Share Tools
Your Cart: (0) Total: $0.00
View all products by Pure Prescriptions
90 Softgels
$75.00  $59.90
90 Softgels
$75.00  $59.90
180 Softgels
$145.00  $110.00
*Super Savers Always SAVE More!
Choose when your product auto-ships & get a FREE upgrade to Pure+ Same Day Shipping, a $7.95 Value!
Tell me more about the benefits
AutoShip Every:
Add to Cart
In Stock, Fast Shipping!

Customer Rating: 123 Reviews

... Developed by the same researcher who originally discovered and developed nattokinase, Dr. Hiroyuki Sumi, the award winning Cardiokinas® represents the benchmark by which all other brands of nattokinase are measured ...
Winner of the prestigious Nutrition Business Journal's product merit award, Cardiokinas® features a new patented nattokinase (pronounced nat-oh-KY-nase). Nattokinase is an enzyme that is extracted from the traditional Japanese soy food called "natto." Nattokinase was first discovered by Dr. Hiroyuki Sumi, PhD.
Natto has been used traditionally to support cardiovascular health. Modern research has revealed that nattokinase works by breaking down fibrin, a protein involved in clotting of the blood.
Why You Should Buy It

  • Supports healthy blood clotting*
  • Promotes healthy whole blood viscosity*
  • Improves overall circulation*
  • Keeps blood cells from sticking together*
  • Maintains blood pressure levels already within normal range*
  • The Bottom Line: The Cardiokinase® brand of nattokinase is the winner of the prestigious Nutrition Business Journal's product merit award. Pure Prescriptions was one of the very first companies to introduce nattokinase to the the dietary supplement industry in 2001. Cardiokinase® was developed by Dr. Sumi, the discoverer of nattokinase and can be trusted for safety and effectiveness. Cardiokinase® is a genuine form of nattokinase and the exact same material used in scientific studies. Additionally, Cardiokinas® comes in high potency soft gels for enhanced absorption.

    Real Help From Real People, Online or by Phone
    Unlike other companies on the web, we have healthcare professionals standing by to answer any questions you may have about nattokinase. If you need information about the health benefits of nattokinase or nattokinase dosage, please do not hesitate to call us (800) 860-9583 or Live Chat with us.

The Japanese Have Similar Cholesterol and Blood Pressure Levels as Americans — Yet Their Hearts Are Much Healthier. Why?

Maintaining normal cholesterol and blood pressure levels is essential for cardiovascular health. But there’s another key factor many people, even cardiologists, often overlook: blood clotting.

If your blood does not clot enough, even simple cuts or bruises can turn into life-threatening injuries. But if your blood clots too much, your blood becomes more thick, or viscous — slowing down your circulation.

One fundamental difference between the Japanese and the American diet is that Japanese citizens consume over 50,000 tons of a traditional fermented soy food called natto each year, while Americans eat none. Could that account for the difference?

Natto: Japanese Superfood Natto naturally contains the enzyme nattokinase, discovered by Dr. Hiroyumi Sumi in 1980. Several published studies have shown that nattokinase promotes healthy blood clotting and normal blood viscosity, which helps blood flow more easily through the veins.* Yet not all nattokinase is the same.

Cardiokinase™, winner of the coveted 2009 Product Merit Award by Nutrition Business Journal, is a new and improved version of nattokinase developed by Dr. Sumi himself.

Why Cardiokinase™ is Superior

  • More effective: 20% better efficacy
  • Better absorbed: 10% better lymphatic absorption
  • Superior strain: Derived from the powerful Naruse (N) strain
  • Standardized: Standardized for potency utilizing the IU test for activity — not FU
  • Non-GMO: Derived from non-GMO soybeans
  • Hypoallergenic: Contains no corn-derived stabilizers


About Cardiokinase™

Developed by the same researcher who originally discovered nattokinase, Dr. Hiroyuki Sumi, Cardiokinase™ represents the new gold standard of nattokinase.

The Story of Nattokinase 

In 1980, Dr. Sumi was doing research at the University of Chicago to find a substance that could help maintain the body’s normal fibrinolytic activity, or ability to break down blood clots. One day he was eating his lunch — a traditional Japanese dish made from fermented soybeans called natto — when inspiration struck. He decided to test the fibrinolytic activity of natto. To his surprise, it turned out to have the best fibrinolytic activity of the nearly 200 foods he had tested. He isolated the enzyme responsible and named it nattokinase.

Nattokinase Comparison Chart
See how your Nattokinase stacks up

  Cardiokinase™ NSK-SD™ Other Brands
Exclusively Developed by Dr. Sumi dr sumi nattokinase    
Improves Circulation nattokinase endometriosis benefits of nattokinase Not Known
Moderate Fibrinolytic Activity   best nattokinase review Not Known
High Fibrinolytic Activity nattokinase serrapeptase
20% more Fibrin Units (FU) per capsule than NSK-SD; Exceeds all current standards
  Not Known
Lowers Whole Blood Viscosity fda nattokinase   Not Known
High Bioavailability nattokinase and peyrones disease
10% better lymphatic absorption than NSK-SD
Standardized for Potency nattokinase powder    
Derived from Organic Non-GMO Soybeans japanese nattokinase    
Hypoallergenic Non-Corn Excipients doctors best nattokinase    
Derived from Powerful Novel "N" Strain nattokinase and hair growth    
Composition Patent nattokinase for high blood pressure    
Clinical Trials nattokinase stroke order nattokinase  

Important Notes:
Other Brands in this comparison chart are considered to be any proteolytic enzyme (bromelain, papain, fungal enzymes). These brands are based upon a false identification of FUs activity and are not nattokinase. (See note below from Dr. Holsworth explaining this in detail)

Since my introduction of nattokinase as a safe and effective therapeutic modality into the clinical and hospital setting in 2002, I have been searching for a standardization of nattokinase that will allow health professionals to determine two important facts concerning the use of nattokinase;

1. Biochemical validation that the substance is nattokinase, specificity

2. Accurate determination of fibrinolytic activity in vitro, sensitivity

The previous standardization of nattokinase identified activity in fibrinolytic degradation units (FUs). Unfortunately, the test does not validate whether the enzyme is in fact, nattokinase. Any proteolytic enzyme (bromelain, papain, fungal enzymes) tested using this test would erroneously report fibrinolytic activity or the ability to degrade cross-linked fibrin. Many companies manufactured, produced and falsely identified their bulk and/or finished retail products as "nattokinase" based upon a false identification of FUs activity. Can you imagine a physician prescribing insulin that was not truly insulin or the units of the insulin were incorrect? Many patients' lives depend upon securing a valid form of nattokinase and accurate determination of its activity because they do not have a pharmaceutical drug such as an anti-coagulant that they can tolerate and/or is effective in the prevention of their condition of inadvertent blood formation.

In addition, the substrate utilized in the previously standardization for determining the activity was not soluble so activity determinations were inaccurate and not reproducible.

Dr. Hiroyuki Sumi, Ph.D., a medical researcher in thrombolytics who discovered nattokinase in the 1980's, has developed and published a new standardization method that validates not only the biochemical identification of the enzyme as nattokinase but also the activity or ability of nattokinase to degrade or lyse cross-linked fibrin in International Units. Now, physicians and patients are insured that they are receiving authentic nattokinase in a stable and quantified amount of activity to address various medical indications.

Dr. Ralph Holsworth

Nattokinase Pioneer & Researcher

buy nattokinase

What is Cardiokinas®?

Award Winning Cardiokinase features a new patented nattokinase. Nattokinase is an enzyme that is extracted from the traditional Japanese soy food called "natto." Nattokinase was first discovered by Dr. Hiroyuki Sumi, PhD. Natto has been used traditionally to support cardiovascular health. Modern research has revealed that nattokinase works by breaking down fibrin, a protein involved in clotting of the blood.*

What makes Cardiokinas® Different?

Cardiokinas® stands apart by using only 100% New, more powerful and reliable Nattokinase.

Hypertension is among the many illnesses associated with an unhealthy lifestyle. When left untreated, hypertension can contribute to the formation of atherosclerosis. Hypertension and atherosclerosis are the key risk factors to cerebrovascular and cardiac disease.

In 1980, Dr. Hioryuki Sumi discovered that "natto," a traditional fermented food in Japan, possesses previously unidentified thrombolytic activity. He referred to the isolated enzyme as nattokinase. Although nattokinase is not new to the marketplace, there is a new strain that exhibits some exceptional improvements over the original. It should be appropriate then that Dr. Sumi himself set the new bar with the scientific development on this new substance. We will highlight some of the key advancements that clearly delineate it from any other nattokinase on the market. This new product is called Cardiokinase (CK).

best nattokinase
Is Cardiokinas® Safe?

Cardiokinase brand of Nattokinase is safe and effective because it has been tested. Studies have shown that the Nattokinase in Cardiokinase is safe for the vast majority of people. This comes as no suprise to researchers, given that nattokinase is a natural product and that the soy food called natto has been eaten safely in Japan for about 1,000 years.
nattokinase side effects

It's essential that nattokinase doesn't include Vitamin K in order to prevent an adverse interaction with drugs such as Coumadin®. Thus, our patented process extracts all traces of Vitamin K. Cardiokinase (Strain N) studies have confirmed the safety. Cardiokinase contains an unprecedented high activity of nattokinase, more than 200% the effectiveness of other nattokinase products. Simply put, if it's not Cardiokinase, you're not getting the best.

So when it's difficult to tell the difference between one nattokinase and another, trust the one that's been tested, proven and is more effective.

New Nattokinase Information

1. CK utilizes a new standardization for fibrinolytic activity which is more sensitive and specific to nattokinase activity. Originally, the Fibrin Unit (FU) method was created for the sake of convenience. Because fibrin, which is insoluble in water, is used as the substrate, accurate measurement of the enzyme reaction is not possible through this method. Therefore, to accurately measure the potency of CK, International Units (IU) are required to quantify the results of the enzyme activity.

2. Cardiokinase incorporates a new strain (“strain N”) of Bacilius Substilisin that produces higher activity than other strains. In particular, the cultured solution of the CK (N strain), displayed activity that was 17.9 times greater that of the control. Furthermore, fibrinolytic activity was also observed in the bacteria itself, and the activity on the N strain elevated to a level that was 70 times as much as the control. The therapeutic benefit of this type of activity on human cells is the promotion of the release of tissue-plasminogen activator (t-PA). t-PA is a protein involved in the breakdown of blood clots – it catalyzes the conversion of plasminogen to plasmin, the major enzyme responsible for clot breakdown.

3. In addition to t-PA, CK has demonstrated a new mechanism of action involving fibrinolytic pharmacokinetics. This new strain of nattokinase has shown for the first time that is has a higher kinin-producing capacity than plasma kininogen. The physiological activities of kinin (and its products like bradykinin) include lowering blood pressure, promotion of capillary permeability, local vasodilation, smooth muscle contraction, promotion of lymph flow, and inflammatory modulation. This kinin-producing activity is involved in the circulatory systems of all internal organs.

Cardiokinase's hypotensive and circulation-improving effects have the potential to replace other more invasive and ADR-promoting medications in the conventional and alternative marketplace.

4. Another novel characteristic of CK is its anti-viscogenic effect. No other natural substance has demonstrated the ability to quantitatively lower blood viscosity as CK has. The applications of this attribute alone make CK one of the most useful therapies in even the most serious cardiovascular conditions.

5. Lastly, unlike other commercial sources of nattokinase, Cardiokinase incorporates a non-corn source of maltodextrin, making it the most hypoallergenic source of nattokinase on the market.

The advantages of improved circulation are self-evident. Applications for CK can be elucidated paying special consideration to its fibrinolytic activity and anti-viscogenic effect. From cosmetics to heart and brain health, improved blood flow is a ubiquitous benefit for the human body.

Customers who purchased "Cardiokinase™ (Nattokinase)" also purchased:
Antioxidant Green Drink
by Pure Prescriptions
1 Canister
pure encapsulations
Homocysteine Factors
by Pure Encapsulations
180 Capsules
pro omega fish oil
by Nordic Naturals
60 Softgels
Cardiokinase™ (Nattokinase)
by Pure Prescriptions
90 Softgels


Supplement Facts:

Suggested Use: As a dietary supplement, take 3 SoftGels daily. For best results, take additional SoftGel at bedtime.

One (1) SoftGel Contains:

Ingredients AMT %DV
Serving Size: 3 SoftGels - -
Servings Per Container: 30-90 -
Each 100 mg SoftGels Contains: - -
Nattokinase (Strain N)
100 mg (25 IU) -

Other Ingredients: Gelatin and Glycerin (Softgel) Soybean oil, Glycerin fatty ester, Bees wax.

Allergen Statement: This product contains soy. No gluten, milk derivatives, or artificial colors or flavors.

(-) There is no %DV or the manufactuer has not provided this data.
Watch Cardiokinase Video
5 star rating5 star rating5 star rating5 star rating5 star rating Cardiokinase™ (Nattokinase), 4/20/2016
Reviewer: Verified Purchase
See all my reviews
I'm happy with product and continue to reorder.
5 star rating5 star rating5 star rating5 star rating5 star rating Cardiokinase™ (Nattokinase), 4/6/2016
Reviewer: Verified Purchase
See all my reviews
I use Cardiokinase to control my \nPolycythemia Vera problem and it seems to be working very well
5 star rating5 star rating5 star rating5 star rating5 star rating Cardiokinase™ (Nattokinase), 3/28/2016
Reviewer: Verified Purchase
See all my reviews
I have only just begun to take this product, but already I notice the cramping in my feet and legs has diminished.
5 star rating5 star rating5 star rating5 star rating5 star rating Cardiokinase™ (Nattokinase), 2/21/2016
Reviewer: Verified Purchase
See all my reviews
Had 5 strokes in July and use it to keep my blood flowing properly and since I'm writing this it obviously is working.
5 star rating5 star rating5 star rating5 star rating5 star rating Cardiokinase™ (Nattokinase), 1/9/2016
Reviewer: Verified Purchase
See all my reviews
Started to use the Cardiokinase after a couple of strokes in July. Being a suspenders and belt type of guy I've been on the Cardiokinase and *** my doctor subscribes. No more strokes...
read complete review
View All 123 Reviews
Join us on Facebook

To Order, Call Toll Free:
1.800.860.9583 M-F 8am-5pm
*These statements have not been evaluated by the FDA. Products are not intended to diagnose, treat, cure or prevent any disease.
© 2017. Pure Prescriptions, Inc. All Rights Reserved. Site Map