SR-CoQ10 with Vitamin PQQ: A powerful combination for cardiac, neural and cognitive health. Vitamin PQQ and CoQ10 promote antioxidant and mitochondrial health through different mechanisms, providing multifunctional support for cardiovascular health and neuroprotection. In a double-blind, placebo-controlled clinical trial conducted in 71 middle-aged individuals, BioPQQ™ supplementation over a 12 week period supported healthy cognitive performance, specifically high-end mental processing.*
What Is It?
PQQ (pyrroloquinoline quinone) is a novel cofactor with
antioxidant and B vitamin-like activity. It is naturally
present in vegetables and in the human body, including
breast milk, and posseses unique neuroprotectant
and cardioprotectant properties. MicroActive CoQ10 is a
water-soluble, submicron particle-sized CoQ10 generated
using a patented process that complexes each CoQ10
molecule with a beta-cyclodextrin molecule. CoQ10 is
bound to the lipophilic end of the molecule, while the other
end is hydrophilic, facilitating dispersion and transport.
At the cellular surface, the complex dissociates, liberating
a single CoQ10 molecule for efficient absorption. The
extended 24-hour release of MicroActive® CoQ10 also
allows for convenient, once-daily dosing. Clinical research
indicates superior absorption compared to solubilized
and crystalline CoQ10, with low inter-subject variance.*
Figure 1. SR-CoQ10 absorption in human volunteers.
Comparison of the mean plasma CoQ10 concentrations
after a single oral dose of either SR-CoQ10 or solubilized
Uses For SR-CoQ10 with PQQ
PQQ and CoQ10 provide
antioxidant and mitochondrial support through different
mechanisms, providing multifunctional support for
cardiovascular health. Research indicates that both PQQ
and CoQ10 support heart muscle function and healthy
cellular oxygen utilization. However, the mechanisms
for this support differ. Studies suggest that PQQ
promotes mitochondrial synthesis and function, while
CoQ10 promotes energy production as a core component
of cellular respiration. These actions are particularly
supportive of tissues that require a lot of energy, such as
the heart muscle. Furthermore, they acts as antioxidants,
providing protection from free-radicals and helping to
maintain the integrity of cellular membranes.*
Nerve and Cognitive Health: Numerous studies have
indicated that PQQ supports nerve health. Mechanistic
investigations suggest that PQQ supports several signal
transduction pathways that are important in maintaining
mitochondrial homeostasis and oxidative metabolism.
Like CoQ10, PQQ is a powerful antioxidant that supports
mitochondrial function. PQQ also supports healthy
levels of nerve growth factor and glutamate receptor
activity. Several studies suggest that PQQ may promote
learning ability and memory. In a double-blind, placebocontrolled
clinical trial conducted in 71 middle-aged
individuals, PQQ supplementation over a 12 week
period supported healthy cognitive performance, and a
combination of PQQ and CoQ10 provided greater support
than PQQ alone.*
What Is The Source?
BioPQQ™ pyrroloquinoline quinone disodium salt is
manufactured in Japan using a patented natural
fermentation process. It contains 2.7 mg sodium per
capsule. MicroActive® CoQ10-cyclodextrin complex
(SR-CoQ10) contains coenzyme Q10 obtained naturally
from fermentation and potato starch. Hypo-allergenic
plant fiber is derived from pine cellulose.
Pure Encapsulations recommends 2 capsules daily, in the
morning, with a meal.
For educational purposes only. Consult your physician for any health problems.
Are There Any Potential Side Effects Or
If pregnant or lactating, consult your physician before taking
this product. At this time, there are no known side effects or
precautions. Consult your physician for more information.
Are There Any Potential Drug Interactions?
CoQ10 may react with blood thinning medications. Consult
your physician for more information.